Rode wijn - 19 Januari 2012 09:00

Dit soort artikelen zijn heel populair in de lekenpers. Wat is er leuker dan te berichten dat rode wijn uw testosteron verhoogt (god voor uw spiermassa) en ook nog eens borstkanker tegen gaat. Maar u moet wel heleboel er bij verzinnen, of zoals dat heet extrapoleren. lees maar mee met het oorspronkelijke abstract (Engelstalige samenvatting van het oorspronkelijke artikel)

Red Versus White Wine as a Nutritional Aromatase Inhibitor in Premenopausal Women

Chrisandra Shufelt, M.D., M.S.,

1 C. Noel Bairey Merz, M.D.,1 YuChing Yang, Ph.D.,1

Joan Kirschner, M.S.N., N.P.,

1 Donna Polk, M.D.,2 Frank Stanczyk, Ph.D.,3

Maura Paul-Labrador, M.P.H.,

1* and Glenn D. Braunstein, M.D.1

Abstract

Background:

An increased risk of breast cancer is associated with alcohol consumption; however, it is controversial

whether red wine increases this risk. Aromatase inhibitors (AIs) prevent the conversion of androgens to

estrogen and occur naturally in grapes, grape juice, and red, but not white wine. We tested whether red wine is a

nutritional AI in premenopausal women.

Methods:

In a cross-over design, 36 women (mean age [SD], 36 [8] years) were assigned to 8 ounces (237 mL) of

red wine daily then white wine for 1 month each, or the reverse. Blood was collected twice during the menstrual

cycle for measurement of estradiol (E2), estrone (E1), androstenedione (A), total and free testosterone (T), sex

hormone binding globulin (SHBG), luteinizing hormone (LH), and follicle stimulating hormone (FSH).

Results:

Red wine demonstrated higher free T vs. white wine (mean difference 0.64 pg/mL [0.2 SE], p = 0.009)

and lower SHBG (mean difference

- 5.0 nmol/L [1.9 SE], p = 0.007). E2 levels were lower in red vs. white wine

but not statistically significant. LH was significantly higher in red vs. white wine (mean difference 2.3 mIU/mL

[1.3 SE],

p = 0.027); however, FSH was not.

Conclusion:

Red wine is associated with significantly higher free T and lower SHBG levels, as well as a significant

higher LH level vs. white wine in healthy premenopausal women. These data suggest that red wine is a

nutritional AI and may explain the observation that red wine does not appear to increase breast cancer risk.